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The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis
1Y6X
Primary Citation

The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.

Javid-Majd, F.,  Yang, D.,  Ioerger, T.R.,  Sacchettini, J.C.

Journal: (2008) Acta Crystallogr.,Sect.D 64: 627-635

PubMed: 18560150  
PubMedCentral: PMC2631106  
DOI: 10.1107/S0907444908007105  
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PubMed Abstract:
Phosphoribosyl-ATP pyrophosphohydrolase is the second enzyme in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP to phosphoribosyl-AMP and pyrophosphate. It is encoded by the hisE gene, which is present as a separate gene in many bacteria and archaea but is fused to... [ Read More & Search PubMed Abstracts ]
 
  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 10332.60
    Molecule: Phosphoribosyl-ATP pyrophosphatase
    Polymer: 1 Type: protein Length: 93
    Chains: A
    EC#: 3.6.1.31   
    Organism Mycobacterium tuberculosis
    Gene Names hisE MT2182
    UniProtKB:   Protein Feature View | Search PDB | P9WMM8  
    P9WMM8Molec. ProcessingPhosphoribosyl-ATP pyrophosphataseE.C.3.6.1.31: Phosphoribosyl-ATP diphosphataseUniProtKBSCOP domainsall-alpha NTP pyrophosphatases Secstruc1Y6X.APDBTooltip
     
  •   Structure Validation Hide

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  •   Source Hide
    Polymer: 1
    Scientific Name: Mycobacterium tuberculosis   Taxonomy   Expression System: Escherichia coli  
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    MSE
    Search      		MSE C5 H11 N O2 Se MET lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide

    Information from the Structural Biology Knowledgebase  

     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly 1       
Symmetry: C2 view
Stoichiometry: Homo 2-mer - A2
Biological assembly 1 assigned by authors
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  •   Deposition Summary Hide
    Authors:   Javid-Majd, F.,  Sacchettini, J.C.,  TB Structural Genomics Consortium

    Deposition:   2004-12-07
    Release:   2005-03-01
    Last Modified (REVDAT):   2011-07-13
     
  •   Revision History    Hide
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    2011-07-13
    Version format compliance
    2011-07-13
    Biological assembly
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   1.25
    R-Value: 0.183 (work)
    R-Free: 0.207
    Space Group: I 2 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 37.92 α = 90.00 
    b = 62.60 β = 90.00 
    c = 67.05 γ = 90.00 
     
Biological Assembly Image for 1Y6X
The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis
Protein chains are colored from the N-terminal to the C-terminal using a rainbow (spectral) color gradient

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